Women religious, lady doctors, political activists, and graduate nurses fundraised for hospitals to address the physical and moral afflictions in growing cities—and provide professional opportunities for the managing group. An immediate concern shared among women’s groups was their ability to secure and outfit a “suitable” building for their cause. The hospitals they built reflected the negotiability of late nineteenth century American medical practice and women’s diversely imagined and implemented hospital solutions for healthcare crises in their cities. This paper foregrounds the specific, intentionally curated spaces in which women’s hospital collectives brought forth their visions of modernizing medicine and roles for women in the professional medical landscape. Working in buildings “sacrificed” for the care of the sick, women’s collectives and the hospitals they founded became vital, durable institutions in urban centers of the American West.