This paper examines how confessional differences shaped imperialism and the process of colonizing indigenous peoples, using the case study of Guanabara Bay where the French Protestants and Portuguese Catholics were present. I will analyze Jesuit notions of empire and evangelization, through the medium of the epic poem. José de Anchieta, S.J.’s first work, De Gestis Mendí de Saa, was the first epic poem concerning the American continent ever to be published. The poem recounts the first three years of the Portuguese Governor General Mem de Sá’s time in Brazil, while the Portuguese fought against the French presence in Guanabara Bay. Anchieta reinforces Mem de Sá’s role as colonizer of both his indigenous enemies and the French. The classical tradition is utilized in new ways as Anchieta realizes that he must preach Catholicism to the indigenous peoples while simultaneously fighting Protestant heresy.